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2025-09-10 Science & Technology
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FDA approves first clinical trials transplanting pig organs into humans
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 [Daily Mail, where America gets its news] The FDA has approved the first clinical trials for human use of genetically modified pig organs to address the severe organ shortage crisis.
The move comes after three patients in the US successfully received genetically engineered pig kidneys, known as an EGEN-2784 kidneys, in the past year.
Massachusetts-based biotech company eGenesis and Mass General Brigham in Boston will provide the same gene-edited pig kidney transplants to 30 people age 50 or older who are on dialysis and the organ transplant list.
Genetically modified kidneys for xenotransplantation (the process of grafting or transplanting organs or tissues between members of different species) are created by using gene-editing technology, such as CRISPR/Cas9, to alter the DNA of pig embryos before they are born.
This involves removing pig genes that can trigger a strong immune response or cause the organ to grow too large, inactivating pig viruses that could infect humans, and adding human genes to improve compatibility with the human immune system.
All US transplants of animal organs into living humans have received FDA approval on the grounds of 'compassionate use,' which is meant for cases in which the person's life is at risk and there are no comparable treatments.
But so far, there have not been clinical studies for widespread human use.
Bill Stewart, 54, from New Hampshire, is been the latest patient to receive a gene-edited pig kidney and he is faring well after his June 14 operation.
Meanwhile,
...back at the Council of Boskone, Helmuth ordered the entire 614th quadrant searched. The Green Lensman must be found!...
a pig kidney has kept another New Hampshire man, Tim Andrews, off dialysis for a record seven months, and Richard Slayman, then aged 62, was the first ever patient to have survived after an organ transplant from an animal in 2024.
Slayman died two months later.
In January 2022, surgeons performed a heart transplant from a pig to human for the first time ever. The patient died after two months with the organ.
Until now, the longest that a gene-edited pig organ transplant was known to last was 130 days.
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