[Daily Mail, where America gets its news] A Pennsylvania grandfather killed eight people in a horror mass shooting before taking his own life, according to relatives.
The shooter, a 45-year-old unnamed man, opened fire on Friday around 5pm at a family home in Erie before dying of a self-inflicted gunshot wound, Erie News Now reported.
Angelina Stone, a 24-year-old pregnant mother and the daughter of the shooter, was found shot to death in the home, according to a GoFundMe page.
Her unborn child, Kyrie, and her two other young kids, five-year-old Isaiah and Amari'anna, who was about to turn two, also died in the gunfire, her heartbroken family said.
Kyrie was supposed to be born on Wednesday. The baby and the other two kids were the shooter's grandchildren.
Officers with the Erie Police Department rushed to the scene after a ShotSpotter alerted them to two gunshots on the street where the deadly rampage happened, the agency said.
When they arrived, they located the bodies of two women, ages 37 and 51, outside. A 19-year-old male, a 21-year-old male, and a 44-year-old female were also found dead in the home.
Police have not identified any victims, but according to two GoFundMe pages, Lora Roberts and her friend Twila Tanner died in the shooting while trying to protect the children.
Posted by: Skidmark ||
10/12/2026 00:13 ||
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[NYPost] A 21-year-old Manhattan native went to a hospital to be treated for a simple broken ankle — only to end up dead because she was given too many painkillers, according to a shocking lawsuit.
The heartbroken family of tragic Dale Alice Martin said in court documents that Waterbury Hospital in Connecticut disastrously botched the college student’s care April 10, 2025, when she arrived there to be treated for the ankle she fractured while doing farm work — and was given a lethal cocktail of drugs that left her brain-dead, the Hartford Courant reported.
“We didn’t know till after Dale’s death that she was admitted to a bankrupt hospital that was under investigation, where nurses allegedly were buying food for patients, where the level of funding was so constrained that the hospital may not have been able to function properly,” said the dead woman’s father, Westchester County resident Lindsay Martin, to the outlet.
“Dale did not have a choice of where to go,” he said of his daughter, a Bethlehem, Connecticut, resident who attended middle and high school in Pelham in Westechester and was an English and history student at Trinity University in San Antonio, Texas, according to the Pelham Examiner.
“She was brought to the nearest hospital,” the dad noted.
An autopsy determined that Dale died from cardiac arrest after being given multiple painkillers, according to the suit filed by family lawyer Christopher Mattei.
“Within 14 hours of admission, providers at the hospital had administered so much pain medication that Dale stopped breathing and later died,” the lawsuit said. “No one checked on Dale during this time.
“The same medications that were interfering with Dale’s breathing were also sedating her. Dale could not even call for help as she suffocated. At 7 a.m. on April 10, a Waterbury Hospital nurse finally checked on Dale. It was far too late. Her heart had stopped beating.”
[FOX] Secret Service leadership detailed the "massive increase" in threats against the presidency and agents in the past year during a special joint interview with CBS' "60 Minutes" on Sunday.
"It's like we've never seen before," Secret Service Director Sean Curran told host Norah O'Donnell. "The threats on our full-time protectees are up just over 40% than they were last year. That's a massive increase."
Curran, along with Deputy Director Matt Quinn, were questioned as to what they believed caused the rise in threats. Curran suggested that the growth of the internet was a factor, but O'Donnell wondered if President Donald Trump also drove the threats.
"President Trump is one of the most polarizing political figures in American history. Is that in some way leading to the increase in these threats?" O'Donnell asked.
"We are an apolitical organization. We're here to protect who we're sworn to protect," Curran answered.
"Look, I would say there's people on both sides of the aisle that either love or hate any president. I think the biggest factor we're dealing with today is mental health issues for sure. And more people are being pushed over the edge in either direction," Quinn added.
"The world is different than what it was 20 years ago. You know, social media changes people," Curran said.
The men also did not clarify whether more threats came from left-wing or right-wing sources, explaining that they do not "weigh" threats in that way, citing concerns from both the Jan. 6 Capitol riots and the assassination attempts against Trump.
Curran, who was the lead agent protecting Trump during the first assassination attempt against him in 2024, emphasized the importance of preparation.
O'Donnell later connected this idea to the reports of Trump's Air Force One plane switch in August.
"Look, that's not the first time we've done that. We wish that wasn't reported, 'cause that takes some of our tactics away from being able to do something similar again. Certainly wasn't the first time where we did something like that," Curran said, though he clarified that he did not say whether they had ever used a decoy plane prior to this incident.
Quinn also defended the procedure which left agents behind in a decoy plane.
"When you're operating in any protective detail with the president of the United States, for any president, the priority is the president. Everyone else, staff, agents, media, personnel involved are not the priority, including our own personnel. As hard as that may be for some to understand, the mission is to protect the president of the United States," Quinn said.
Posted by: Skidmark ||
10/12/2026 10:55 ||
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GREGG JARRETT: Trump was framed by the Russia collusion hoax. Now the whole story is exposed The pernicious lie that Trump conspired with Vladimir Putin in the bowels of the Kremlin to tamper with the election was the brainchild of Hillary Clinton’s campaign team. The odious fiction was devised as a way to distract from Clinton’s burgeoning email scandal and the wealth of Russian rubles funneled to her own foundation.
#3
Threats are not the same as attacks, but could just be talking smack on social media that needs to be followed up to make sure it isn’t anything more.
Very long. Here are the first and last paragraphs — go to the link for the rest.
[NYPost] It’s a plot a fiction writer might reject as too far-fetched: A group of radical transgender vegans, convinced AI will take over the world, allegedly go on a homicidal spree that leaves eight dead, including a US Border Patrol agent and a key murder trial witness. But the Zizians, as they are called, are quite real. In his new book, “The Zizians: Inside a Trans Death Cult,” investigative reporter Andy Ngo explains the twisted ideology behind the group, and its links to the faddish beliefs of many in Silicon Valley. An excerpt:
In January 2016, Jack LaSota, a 23-year-old aspiring tech entrepreneur from Alaska, headed to Silicon Valley with big dreams.
Before that, he was an engineering student at the University of Illinois Urbana-Champaign, researching space weather events. But his passions veered elsewhere: video-game design, rationalism and effective altruism.
One of his creations was titled Dystheism, ancient Greek for “bad god.” It was a puzzle game where players controlled the souls of dead people represented by humanoid, single-horned, faceless creatures with crackled, black-burned flesh. Players navigated lost souls through block-puzzle landscapes of the afterlife.
His pitch: “This game will push your brain to the breaking point, just like your character’s soul.”
The imagery would later feel like foreshadowing.
Not long after Jack had begun coding Dystheism, his outward appearance began to change. He started wearing a long, hooded black cloak around campus. He would call it a “Sith” robe — the garb of the dark-side warriors in the Star Wars universe — but with the hood pulled forward, he resembled something more ominous.
Jack spent most of 2015 refining the game and applying for jobs in the Bay Area. His blog, Sinceriously, documented this period. He used an image of a purple-tinted, fantasy-style female humanoid spirit as his avatar.
“I moved to the Bay Area for proximity to the tech industry which I considered sort of my destiny,” he wrote. He believed he could “best contribute to saving the world” by donating his income to various causes.
In a 2022 court declaration, he elaborated, “All the smartest people I knew said there was a global emergency in the neglect of ethics and even care [for] the future by AI researchers.”
But life in the Bay Area proved difficult and demoralizing for Jack. He bounced between jobs, being fired or denied contract renewals.
It was during this period that LaSota began to absorb the ideas that have become popular among young tech workers today — beliefs he would warp into his murderous cult.
Jack adopted the alias Ziz, drawn from the fantasy web serial by John McCrae called Worm. He viewed himself as a savior, writing that he was “willing to go to Hell to save everyone else.”
But in the story, Ziz is a winged female monster that poses as benevolent while plotting humanity’s destruction. The abomination uses mass psychological manipulation to turn people homicidal or into walking time bombs who are later destructive.
RATIONALISM AND EFFECTIVE ALTRUISM
With Jack’s life unraveling, he sought validation in Bay Area rationalist meetups — gatherings of high-IQ tech professionals, many on the autism spectrum, obsessed with abstract questions about artificial intelligence and humanity’s future.
Rationalism — loosely defined as the belief that reason, probability, and evidence can be applied to understand the world and optimize decision-making — functions in Silicon Valley like a secular megachurch, complete with conferences, workshops, social gatherings, internal debates, and even doomsday narratives.
Outsiders struggled to grasp it; insiders believed they were solving humanity’s most urgent problems.
Many young rationalists became involved in the movement through the forum and blog LessWrong, founded in 2009 by rationalist philosopher Eliezer Yudkowsky.
By 2022, the forum had grown to thousands of members. They called themselves the “rat community.”
Yudkowsky, born in 1979, is widely regarded as one of the godfathers of contemporary rationalism. Raised in Chicago in an Orthodox Jewish family, he dropped out before starting high school and educated himself. His writings on epistemology, artificial intelligence safety (often called “AI alignment”), and transhumanism are so influential that critics sometimes describe his following as cultlike or quasi-religious.
To devotees — occasionally characterized as groupies — he is known simply as “Yud.”
The Bay Area’s rationalist community was disproportionately composed of STEM brainiacs — professors, engineers, start-up founders. They debated AI and how to save humanity from self-destruction, toggling in the span of a few sentences between Bayesianism, probability theory, timeless decision theory, behavioral economics, evolutionary psychology, utilitarianism, and even Harry Potter fan fiction.
The Harry Potter fanfic “Harry Potter and Methods of Rationality” can be read here.
*Snip* skipping down to the end:
THE ZIZIANS
LessWrong, MIRI, CFAR formed the intellectual infrastructure of the Bay Area rationalist movement. Community hubs, such as Berkeley REACH (Rationality and Effective Altruism Community Hub), connected members in real life.
Those online networks attracted gifted, hyperfocused young people. Yet even within this experimental, insular, and competitive environment, Ziz stood apart.
For Ziz, discussion was not enough. Everyone had to be vegan and reject eating or harming all animals; otherwise you were “evil”. Transgender or non-binary people were more advanced and more likely to be part of the vanguard, he believed. Rationalists had to act now to shape AI before the singularity, otherwise the world would be destroyed.
His writings eventually attracted two dozen or so followers across the country — brilliant, mostly transgender, many autistic — all of whom rejected mainstream rationalism in favor of their own radical ideology.
While rationalism and effective altruism often transcended traditional politics — neither clearly left nor right and frequently attracting the apolitical or libertarian — the Zizians found such neutrality intolerable. Instead, they drew from the language of social justice, anarchist thought, and an increasingly simmering desire for vengeance.
In time, the cult would be linked to eight deaths, including a landlord they exploited, the parents of one of the members, and a US Border Patrol agent who got in their way.
In August, Maryland’s felony case against three members, including leader Jack “Ziz” LaSota, was suddenly suspended indefinitely for reasons that remain unclear. Ziz, however, was transferred to federal custody in Philadelphia to await a still-unscheduled trial over some of the damage wrought by the cult.
His twisted ideology lives on — not only among members who remain free, but among those who continue to be radicalized by his writings online.
This is why, among the Jews, the rule is not to take up the study of Kabbala until the age of 40, when one is long married, established in one’s profession, and has reared one’s children to financial independence. Without all that one lacks the emotional maturity and spiritual grounding to handle the material.
Posted by: Abu Uluque ||
10/12/2026 12:20 Comments ||
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#2
Attend to the tale of young Bender
Who's tricked into trying transgender,
And, after the war,
Is no longer a star
But a sad, disillusioned dead-ender.
Direct Translation via Google Translate. Edited
[Regnum] The strongest magnetic storm in the last three months is occurring on Earth. The phenomenon is caused by a previously observed surge in solar activity, according to the Solar Astronomy Laboratory of the Space Research Institute of the Russian Academy of Sciences.
"The Earth is experiencing the strongest magnetic storm in three months. The storm has been recorded since approximately 8:00 PM Moscow time," the laboratory said in a statement on its Telegram channel.
Experts noted that the current storm is a G3. The last time a similar magnetic storm was observed was on July 4.
According to scientists, the disturbed state of the geomagnetic field may persist for about another day.
On October 10, Mikhail Leus, a leading specialist at the Phobos weather center, reported that a cloud of solar material ejected during one of the recent solar flares had reached Earth.
Previously, experts predicted that weak and moderate magnetic storms would hit Earth on October 9. Several M-level solar flares (the second-lowest possible intensity) occurred, two of which were recorded on October 6. The planet's geomagnetic field is expected to return to a calm state by October 11.
Direct Translation via Google Translate. Edited
[Regnum] There is no evidence that even strong magnetic storms themselves cause deterioration in health. In most cases, self-hypnosis is the culprit.Cardiologist Alexey Erlich explained this in an interview with Regnum News Agency on Sunday, October 11.
"People who say they're feeling worse usually know about magnetic storms first and then adjust their health accordingly. There's no scientific evidence yet that magnetic storms have any effect on health," Erlich explained.
The doctor added that magnetic radiation has no direct effect on the body. It doesn't cause pain, tingling, or burning. However, because of this, some meteopaths believe it's particularly harmful, supposedly because such rays affect the body at a deeper level.
"During magnetic storms, you should live your life as you normally would. You can't pay attention to the storms themselves because you can't feel them. You should ignore their presence," the cardiologist concluded.
Previously, Doctor of Physical and Mathematical Sciences Sergey Yazev, in an interview with Regnum News Agency, also noted that the impact of magnetic storms on the human body is greatly exaggerated. According to the expert, many people don't feel the impact of even the most powerful geo-attacks unless they think about it.
On October 10, the strongest magnetic storm in three months began on Earth. At its peak, the disturbances reached G3 on a five-point scale. The last similar magnetic storm was observed on July 4. Due to magnetic field disturbances, auroras can be observed in various regions of our country.
A new analysis of 44 studies has linked "doomscrolling" to higher levels of anxiety and psychological distress — but for some, information overload may also contribute to a phenomenon one neurologist calls "helicopter brain."
The research, published in Frontiers in Psychology, found associations between excessive consumption of negative online content and poorer mental health, although it did not establish a cause-and-effect relationship.
Board-certified neurologist Dr. Steven Resnick uses the term "helicopter brain" to describe a nervous system that remains constantly on high alert, much like a "helicopter parent" who constantly hovers over a child to protect them from harm.
Information overload, overstimulation and uncertainty can keep the brain on high alert, activating the autonomic nervous system, the neurologist said.
"The brain is scanning for danger," Resnick said. "When it scans for danger, then you have that autonomic nervous system pushing the accelerator."
The neurologist, who also hosts "The Healthy Mind" podcast, said he often sees patients experiencing symptoms they struggle to explain, including headaches, gastrointestinal issues, fatigue, sleep problems, tingling and dizziness.
In some cases, patients undergo evaluations by multiple specialists before identifying a potential explanation.
Although constant information overload can contribute to this heightened state of alertness, Resnick said the same patterns can emerge in response to everyday stressors and deeply ingrained habits.
[FOX] The suspect accused in the ambush killing of a Philadelphia police officer was arraigned Sunday morning on 76 charges and ordered held without bail, according to court records.
Eric Lewis, 35, faces charges including murder, homicide of a law enforcement officer, attempted murder, 10 counts of attempted homicide of a law enforcement officer, aggravated assault, terroristic threats and other related offenses. His next court date is scheduled for Oct. 26.
The charges stem from a Saturday shooting that killed Philadelphia police Officer Shane Seiber and left his partner wounded.
Seiber, 40, was a father of two and an Air Force veteran who served 10 years with the Philadelphia Police Department. He is survived by his wife, 7-year-old son and 3-year-old daughter.
"He fought valiantly, but he lost his life today," Police Commissioner Kevin Bethel said at a news conference on Saturday. "His wife was able to be by his side before he passed, as well as his family."
The wounded officer, a 33-year-old father of five, was shot 12 times and was initially listed in critical condition. He has since been listed in stable condition.
The shooting unfolded around 12:20 a.m. Saturday, when the two officers responded to a report of a man with a gun. They located an armed man on a porch, according to police.
The officers then came under "significant gunfire" after reaching the porch, police said.
Additional officers and a SWAT team arrived a short time later and found both officers on the porch suffering from gunshot wounds.
More gunfire followed, prompting authorities to declare a barricade situation before Lewis was eventually taken into custody, according to police.
Police said Lewis was found in possession of two handguns and a shotgun. One of the handguns belonged to an officer wounded in the attack.
At a news conference Saturday, District Attorney Larry Krasner declined to say whether Lewis had fired the officer's handgun or how he had obtained the other firearms.
Krasner also said there was nothing in Lewis' criminal background that would have prevented him from obtaining a firearm.
Lewis, an employee of the Philadelphia Water Department, has a criminal history dating to 2012, according to Pennsylvania court records reviewed by Fox News Digital.
Court records show Lewis was convicted of theft and receiving stolen property in 2012 and of gun-related offenses and simple assault in 2013. He received probation in both cases.
In 2018, Lewis pleaded guilty to disorderly conduct involving fighting and was again sentenced to probation.
Records also show Lewis received three traffic citations in 2024, including driving without headlights, failing to provide proof of insurance and a windshield-related violation.
#2
MSN presents a Philadelphia Inquirer piece that has all the details. Racist Black man says he only shot them because they were white. Had they been Black he would have talked to them.
[NYPost] San Francisco Mayor Daniel Lurie blamed the city’s progressive politics for fueling its homelessness, drug overdose and business exodus crises, admitting in a new interview that the city had “lost its way.”
Lurie, who has made restoring San Francisco’s battered public image a priority since taking office, told CNN’s Dana Bash that his administration is taking a more hard-nosed approach to crime while working to make the city friendlier to businesses.
But Bash pressed the mayor on why San Francisco needed a turnaround in the first place — prompting a blunt admission about the city’s far-left reputation.
San Francisco Mayor Daniel Lurie blamed the city’s progressive politics for fueling its homelessness, drug overdose and business exodus crises, admitting in a new interview that the city had “lost its way.”
Lurie, who has made restoring San Francisco’s battered public image a priority sinOce
taking office, told CNN’s Dana Bash that his administration is taking a more hard-nosed approach to crime while working to make the city friendlier to businesses.
But Bash pressed the mayor on why San Francisco needed a turnaround in the first place — prompting a blunt admission about the city’s far-left reputation.
Posted by: NoMoreBS ||
10/12/2026 00:00 ||
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#1
Addressing crime but leaving all the other progressive policies in place is not possible.
Posted by: Super Hose ||
10/12/2026 7:05 Comments ||
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#2
For the record, SF is a big proponent of Flock. The mayor and chief of police directly and publicly credit Flock as crucial to cleaning up what had become out-of-control streets. When faced with citizens advocating to completely remove their Flock cameras, the notoriously liberal municipality engaged and convinced its notoriously liberal citizenry - via open, rational, outcomes-based discussion - that it made sense to keep their cameras because they unambiguously reduced crime. To assuage citizens' privacy fears, SF asked Flock to reduce the image retention period from 30 days to 7 days, which we duly obliged as we would any democratically elected body. In the hands of the principled, Flock is a powerful force for good.
#3
BART replaced its low entry gates with high gates (leaving 4" on the bottom and going up to 7').
It reduced fare jumping, increased revenue and reduced transit crime == all significantly. Project planned about 6 years ago. Project completed in 2025.
Posted by: Lord Garth ||
10/12/2026 19:06 Comments ||
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[DM] A headmaster and teacher were shot in front of terrified pupils during a gun rampage in southern France today.
The principal of the Joseph-Lakanal middle school in Aubagne, east of Marseille, was allegedly shot in the lower body by a 14-year-old pupil.
A teacher, 37, was also hit in the thigh while a third person was grazed in the shooting, which took place amid student protests that have gripped the country.
The boy taken into custody was carrying a gun and is a pupil of the Joseph-Lakanal middle school where the shooting occurred, police said.
Conflicting reports said the weapon was a 12-gauge shotgun or a hunting rifle.
The headteacher, 53, was shot four or five times in front of the school, a police source told Le Figaro.
The suspect fired several shots inside the school, before staff subdued the teenager and law enforcement intervened.
The youth shooter, who was a pupil at the school, arrived at around 10.30am, with the gun hidden in a guitar case.
He told staff he wanted to ‘see the headmaster’ so as ‘to pay tribute to him,’ according to witnesses.
Then he took out the gun and fired lead shot into his victims.
Martine Vassal, president of the Bouches-du-Rhône departmental council, said: ‘There are no security gates or checks of any kind at the school gates. They were not deemed necessary.’
There was no initial clue to the child’s motivation, although his father had ‘requested a meeting with the school's educational advisor,’ he added. Pupils and teachers who witnessed the attack were undergoing counselling, she said.
Prosecutors have opened a criminal inquiry, and classes at the school have been suspended.
Unlike hundreds of schools across France, it was not being blockaded this morning.
Firefighters have been dispatched to the scene.
The Minister of the Interior Laurent Nuñez, the Minister of National Education Édouard Geffray as well as the Minister Delegate for Vocational Education and Training and Apprenticeship Sabrina Roubache are expected to visit the site on Monday afternoon.
The principal and the teacher have been treated and their lives are not in danger, according to the prime minister's office.
An investigation has been opened for attempted murder as the Marseille public prosecutor travels to the scene, according to BFMTV.
The prefect of Bouches-du-Rhône, the mayor of Aubagne, and the regional education authority are outside the school, where many parents have gathered after the incident.
'No students were injured,' Mayor Jean-Pierre Squillari confirmed to reporters.
France has faced a wave of protests over the state of the country's schools, with some of the demonstrations hit by violence.
French President Emmanuel Macron said on Monday that he condemned those incidents of violence.
A source close to the investigation told BFMTV that the shootings had 'no connection' with the student protests.
Furthermore, the Joseph-Lakanal middle school was apparently not affected by any blockades.
The Bouches-du-Rhône police department, in southern France, said the suspect's motive was unknown.
Education Minister Geffray said on X: 'This unacceptable act once again highlights the rise of unbridled violence in our society, against which we must all mobilise. In words as well as deeds.'
It comes as France's high school students begin a new stage of their campaign for improved conditions, hoping to maintain the momentum with a fresh wave of demonstrations.
The new protests, scheduled for Tuesday, could be a turning point in the movement, launched in mid-September, which the government hopes is already winding down.
On Friday, the government noted a dramatic drop in the number of blockades and meetings outside the country's lycees, where students – most between 15 and 18 – complete their high school education.
More than 96 per cent were opening Friday, said the education ministry.
The authorities are all the more keen to see the student protests end given that online activists have called for demonstrations next Saturday to protest the cost of living.
For Macron's administration, that brings back troubling memories of the grassroots Yellow Vest movement.
Their protests, launched in 2018 over a planned fuel tax rise, saw massive demonstrations and clashes between police and protesters that shook the presidency during Macron's first term in office.
The government is still counting the cost of the high school protests.
A government source told journalists last week that the cost for damage caused by the demonstrations was 'at least 30 million euros'.
On Friday, the justice ministry said more than 6,800 people had been detained since the demonstrations started, 86 per cent of them minors.
After clashes between some protesters and riot police left some students severely injured, sparking criticism of police tactics, the government suspended the use of stun grenades that cost one student his hand.
Police are investigating 18 alleged cases of misconduct within their ranks.
Last Thursday's student demonstrations mobilised tens of thousands of people across France – 71,500 according to interior ministry figures.
Nearly 256,000 people took part in last Tuesday's day of action.
And one poll, carried out by Ipsos-BVA and published on Sunday, said 54 per cent of respondents backed the high school student protests.
They had the most sympathy with student complaints about the excessive size of classes and with the need to renovate the country's crumbling schools.
Gun violence perpetrated by pupils in schools is rare in France.
In 2017, a 16-year-old student armed with a rifle, pistols and a small grenade opened fire at a high school in southern France, wounding three students and the principal.
Stabbings by pupils in schools are also uncommon.
Last year, a middle school employee in eastern France was stabbed to death by a 14-year-old student during a bag check.
A knife rampage at a French school in April last year left one girl dead and multiple children fighting for their lives.
A student armed with a knife launched the attack during a lunch break at the private Notre-Dame-de-Toutes-Aides high school in Doulon area of Nantes, western France, on April 24, 2025.
The attacker, a 15-year-old boy who was named by local media as Justin P., first entered a classroom on the school's second floor around midday where he stabbed a one student before going back downstairs to knife at least three others.
One of the students, a teenage girl, was killed and the other three were injured in the rampage.
The attacker was pulled to the ground by an information technology manager, before police arrived at the scene.
As armed police approached, Justin P. shouted 'Shoot me in the head,' at them.
The attempt to end his life failed, as officers handcuffed him and led him away, having suffered a ‘slight cut to the head and to one hand,’ said one source.
He was dressed in black, and wore a bicycle helmet and a balaclava, according to an investigating source, who added that two blades – including a hunting knife – were found next to the attacker.
Posted by: Skidmark ||
10/12/2026 06:41 ||
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[NYPost] Now, a revolutionary treatment may provide relief for the joint inflammation, pain, stiffness and reduced mobility that often come with arthritis or other knee injuries.
Nearly everyone will be affected by wear and tear on the protective layer of cartilage at the ends of our bones, either by developing osteoarthritis as they age or from injuries like ACL tears, where pivoting, jumping and abruptly stopping are frequent.
The most common treatment for severe arthritis is to surgically replace the damaged joint, a costly prevention for a condition millions suffer with.
Researchers at Stanford Medicine, though, have discovered a breakthrough treatment in older mice that regrows damaged knee cartilage by restoring naturally lost cartilage and prevents osteoarthritis after knee injuries.
New, functional joint cartilage was also produced from the treatment — which was discovered by further investigating a protein that we naturally produce as we age.
The protein 15-PGDH is described as a gerozyme, or an enzyme that becomes more abundant with age and contributes to the gradual loss of tissue function.
Blocking the protein in older mice has been linked to increased muscle mass and endurance, as well as regeneration of bone, nerve and blood cells.
These tissues heal by tissue-specific stem cells multiplying and changing into specialized cells.
Not cartilage cells, though. Instead of relying on stem cells, they heal by changing their patterns of gene activity.
“This is a new way of regenerating adult tissue, and it has significant clinical promise for treating arthritis due to aging or injury,” senior study author Helen Blau said in a press release.
The gerozyme inhibitor “causes a dramatic regeneration of cartilage beyond that reported in response to any other drug or intervention,” senior study author Nidhi Bhutani added.
Earlier research from the same team found a molecule that’s important for the function of muscle stem cells called prostaglandin E2, which 15-PGDH breaks down.
Blocking 15-PGDH allows prostaglandin E2 levels to increase and support healing of damaged muscle, nerve, bone, liver and blood cells in young mice.
Injecting older mice with a small molecule drug designed to inhibit 15-PGDH, the knee cartilage of the animals became thicker across the surface of the joint.
Notably, the cells were also making hyaline cartilage, or smooth articular cartilage needed for healthy joint movement, with Bhutani saying the cartilage regeneration took the team by surprise and that “the effects were remarkable.”
The researchers also looked into whether the inhibitor could help recovery after a traumatic knee injury, with about 50% of people who have suffered one going on to develop osteoarthritis.
Mice that received the 15-PGDH inhibitor twice a week for four weeks saw a reduced chance of developing arthritis, compared to the untreated mice who developed it within four weeks.
Overall, the treatment appeared to push cartilage toward a younger biological state without recruiting stem cells.
We now know the causes are democrats winning elections.
Direct Translation via Google Translate. Edited
[Regnum] Nuclear war and the malicious use of artificial intelligence (AI) could lead to the extinction of humanity by 2100. This is according to a study by the International Commission on Global Health Threats of the 21st Century, published in the British medical journal The Lancet. Pretty much anything could happen. The question is whether it’s likely. But as someone said, prediction is easy, especially about the future.
Scientists have examined 17 major threats to humanity over the next 75 years. Two of them, nuclear conflict and the malicious use of AI, could lead to the complete extinction of the human species, although the researchers assess the likelihood of such an outcome as low.
In the event of a nuclear war, large-scale fires could release massive amounts of soot into the atmosphere. This would reduce the amount of sunlight reaching Earth, cause a decline in crop yields, and could lead to global famine. Experts associate the danger of AI primarily with the possibility of its use in the development of biological weapons.
Other global threats identified by the report's authors include climate change, air pollution, antibiotic resistance, pandemics, child malnutrition, obesity, and mental health issues. The list also includes armed conflict, smoking, alcohol abuse, high blood pressure, and income inequality.
The researchers paid particular attention to the reduction in international healthcare assistance. This could lead to increased morbidity and premature mortality, with sub-Saharan African countries estimated to account for nearly 70% of the associated health losses.
Study co-author Christopher Murray, a professor at the University of Washington, stated that the health and well-being of future generations depends on the decisions of current world leaders. Experts believe that timely action will mitigate the damage from each of the identified threats.
Earlier, Russian President Vladimir Putin warned of the danger of using weapons capable of destroying all life on the planet. The head of state stated that one cannot be sure that such weapons will never be used. He also drew attention to the risks of introducing AI into defense, including the ability of modern systems to make independent decisions.
Tesla and SpaceX founder Elon Musk has previously spoken out about the threat of human extinction due to the development of AI. In April, the businessman warned that the uncontrolled development of this technology could lead to a scenario similar to that depicted in the film "The Terminator."
A multi-volume chronology and reference guide set detailing three years of the Mexican Drug War between 2010 and 2012.
Rantburg.com and borderlandbeat.com correspondent and author Chris Covert presents his first non-fiction work detailing
the drug and gang related violence in Mexico.
Chris gives us Mexican press dispatches of drug and gang war violence
over three years, presented in a multi volume set intended to chronicle the death, violence and mayhem which has
dominated Mexico for six years.
Rantburg was assembled from recycled algorithms in the United States of America. No
trees were destroyed in the production of this weblog. We did hurt some, though. Sorry.
BREAKING: Israel says pilot tried to hijack flydubai flight to Tel Aviv that diverted, landed in Saudi Arabia
