Multiple commercial and passenger vehicles were involved in the crash along interstate 70, ten miles from Terre Haute, per NBC Chicago.
Several of the cars slid across the eastbound side to the median, into the grass, and even toward oncoming traffic on the westbound side of the highway.
Much of western Indiana, including Vigo county where the crash occurred, is under a winter weather advisory until 10am Sunday.
The hazardous weather conditions boasted snowfall up to three inches and wind speeds as high as 35 mph, according to the Weather Channel.
Drivers were warned to 'plan on slippery roads.'
'Slow down and use caution while traveling,' read the warning from the weather service.
Indiana State Police announced that the pileup would cause a six hour traffic halt during one of the busiest weekends of the year for travel.
n a statement to the Daily Mail, Ames reported that there were no major injuries.